Botox for Migraine Botox may also be helpful for treating migraine. It seems that this effect goes beyond muscle paralysis and may actually interefere with the transmission of nerve pain signals. In one study, 48 patients with chronic migraine were evaluated and administered from 25 units to 100 units of Botox-- more than the typical cosmetic-surgery patient gets -- at several sites, including the forehead, temples and sometimes the back of the neck and the shoulders. Three months after the injections, patients responded to a disability evaluation score. Patients reported how or if the Botox Injection had made a difference in whether they had lost work days, social commitments and other effects of headache pain. 58 percent of the patients had a 50 percent or greater reduction in disability. The average decrease in headache frequency was 61 percent; in severity it was 27 percent, and in disability it was 79 percent. Another  researcher found a success rate as high as 92 percent with migraine patients using Botox Injection. Another study found that headache patients on Botox Injection were able to take one-fourth of the medication taken by those who didn't get Botox. Yet another study of 60 migraine patients found those who got two Botox injection sessions over six months had fewer headache days than those who got just one Botox Injection session. Even with this spate of studies, some experts say it's not enough, and obviously more studies are needed. In a small study of 24 patients,75 percent of patients experienced 4 to 6 months of migraine relief following injections of Botox to muscles of the face and head . Another study reported 51 percent of 96 patients reported complete improvement of their migraine pain. Botulinum toxin A injected into the muscles of the brow, eyes, forehead, side of the head and back of the head near the neck (a point that earlier investigators have neglected) induce sometimes immediate headache relief and provide benefit for up to six months. Botox dosage in this case study averaged 80 units per patient. These patients had long-standing diagnoses of migraines, had all seen neurologists, and were taking standard migraine medications, including sumatriptan (Imitrex). Some required narcotic medication to relieve the pain of their frequent headaches. Most suffered migraines on a minimum of once a week and several suffered on a daily basis. It would be a false dream currently to suggest that your migraine could be cured by Botox, but it seems it certainly can reduce the frequency or severity of attacks. You might like to ask your physician if he is happy to inject your temples or other trigger points . Depression and Botox Using Botox to smooth away the frown lines of clinically depressed patients can help them to recover, US researchers found. Nine out of ten depressed patients were no longer depressed two months after Botox treatment on their frown lines.